Canine Revolution Dangers

(http://www.doglogic.com/revolution.htm)

SAGES STORY
On 3/15/00 I asked my Vet for a Heartworm preventive for my 2 year old Australian Shepherd, Sage.  They recommended Pfizer's Revolution for dogs.  It was applied on 3/15/00.  On 3/20/00 Sage developed a cough, but she was otherwise fine. She'd had a bath at the Vet on 3/15/00 also, so I decided to watch her for further symptoms. On 3/23/00 she was fine, until late afternoon when she became quiet and didn't want to play. By 7pm that night, she had trouble opening her left eye and whimpered when she jumped down from the couch or bed.  In the past, Sage always had a tendency to bruise easily.  She had sensitive skin and had worried an area until it had bruised. She had no trouble with her blood clotting and had been previously spayed.She now had bruising on her body.  When I took her to the Vet, he asked if she had been in rat poison.  I informed him that she was an inside dog and only went out to play with the kids and to use the bathroom.  My neighbors have pets and do not put out poisons.  They also asked if she had had a blow to the head because there was blood in the whites of her eyes that was not there yesterday.  I  stated that she was not hit in the head.  I asked if it could be the Revolution and was informed by the Vet that it could not be.  I told my vet that was the only thing that Sage had been exposed to.He did a CBC and her platelets were 87 and WBC count was 27,000. Her Hematocrit (Hct) was 37.  He treated her for infection and rat poisoning and sent us home.  Within 3 hours she was falling over.  I rushed her back to the Vet and he kept her until 5pm that afternoon.  I brought her home after they said she was doing better.At 6pm she was again falling over and I called my Vet back and was informed to bring her back the next day.  By 11pm, she was bleeding from her nose and had vomited with streaks of bright red blood.   My husband and I
drove her to an ER clinic in Savannah, GA and was told that it was either a tick born disease or rat poisoning or a blow to the head.  I again asked if could be the Revolution and was informed no.  They kept her and treated her as my vet.  When I called at 6am, I was informed that she was having seizures but she was otherwise stable.  I was worried about a subdural hematoma and talked with  my Vet.  He suggested I take Sage to Charleston, SC to see a
Specialist.  She arrived there at 4:30pm.  When I gave her history, I again asked if it could be the Revolution and was informed no.  Later that night Sage continued to have seizures and she bled into the orbits of her eyes, but they said their was still hope. At 6:45am they called and said Sage had arrested and was on a ventilator.We asked that they let her go.  This has been devastating to my family. We loved Sage.  She was a family member.  At 10am, the clinic called and asked permission to perform an autopsy.  They informed me that another dog had died last month there, with symptoms the same as Sage.  The dog was an inside dog and the only thing different was that the owner had started Revolution. The dog died of  low platelets and intracranial hemorrhage just like
Sage. (editors note: these symptoms resemble those of  Thrombocytopenia.)The vet in Charleston called the Revolution people (Pfizer) and they are paying for Sages autopsy.  They also paid for the other dogs' autopsy. That autopsy showed  low platelets and intracranial hemorrhage from a toxin. (? Revolution was the only toxin  the owners had given).  I will not know the results of the autopsy for a month, but I presonally believe it could have been the Revolution.  If 2 dogs have died in the Savannah Charleston area in the last month, how many nation wide?Please spread the word for owners to be careful about using this drug on their dogs. No dog should suffer like my Sage suffered. I am simply expressing my OPINION at this point. No proof has been made of our suspicions, but we feel obliged to notify the public of our fears of a potential problem.
Thanks for Listening,
Terri Eddy
Rincon, GAEditors Notes: I verified this information of 4/2/00 by speaking with Terri on the phone. Terri is a nurse, and is knowledgeable regarding drugs and testing. While she is very saddened by the loss of her beloved Sage, she is NOT accusing Pfizer of anything. Instead she wishes other dog owners to exercise caution in the use of this drug until more info is forthcoming. When the results of Sages Autopsy are available, I will publish them here. Here is Terri's Addendum:Attention:  If you have read my previous message concerning Revolution and the death of my dog Sage, please read this message.  This is strictly my opinion until the autopsy reports are back.  I just want people to be cautious when considering using this product on their animals until further evidence is available. Terri EddyFOLLOW UP- FIRST MEDICAL REPORT

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I'm praying as hard as I can.  Mira, our Maltese, was given Revolution by a MI Vet after her Rescue (she was on the wires in MO for TEN years).  It was supposed to be the "Cure All" almost 5 years ago when it was given to her.  Mira, God love her, survived without any major problems but our Vets here in NY said they feel a drug strong enough to kill off so many things is TOO STRONG for them to dispense.  Prayers for Bear and please let us know......

Kay, Puppy, Becce, Mira, and Ivy

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Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST! 
Date: 6/6/2004 9:18:35 PM Central Daylight Time
From: Londeb29@aol.com

To: Pup3


I can't believe it, it happened to my adopted bichon Shelby AKA Sante Fe Sandi on May 14, 2004. I decided to contact Pfizer after my vet politely told me to try it again the next month and if they same thing happened again then I should change flea medication. Pfizer has refunded my money for the Revolution and I am now trying to get paid for the vet bill. The dosage is too stronge for our delicate bichons.  The drug range is under 10lbs or 10 to 20 lbs and Shelby is only 11 lbs which is what the vet told me I needed due to Shelby's increase in weight. My vet gave Shelby a few injections and it took 3 days for her to begin to move around again. She is doing better but has not been the same since. I should have notified my bichon family as I thought this was an isolated incident. I am so sorry I may have been able to save Bear from this terrible toxic drug.
 
Sincerely Debbie Perryman
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Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST!/ Information about Revolution! 
Date: 6/6/2004 4:33:40 PM Central Daylight Time
From: susankoehrn@insightbb.com

To: pup3@aol.com


Canine Revolution Dangers
(http://www.doglogic.com/revolution.htm)


Dale, I have attached a website that describes 2 experiences with Revolution and at the bottom of the site has additional links to get even more info about side effects, etc. It sounds like some very bad stuff. We should all be looking for natural/organic ways to help our babies. Chemicals kill! I hope this info helps even a little. Our bichons cannot handle drugs of any kind. Take care, Susan 
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Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST! 
Date: 6/6/2004 3:48:36 PM Central Daylight Time
From: Nancyhakala@aol.com

To: Pup3


Hi Dale,
 
Thanks so much for the update. There have been many dogs who have become critically ill and have even died from Revolution. :(
 
Praying for this little one's recovery,
 
Nancy

We have had several adverse reactions for Bichons, with revolution. Below is more. Pfizer says it is not recommended for any dog that is sick or weak.


A http://www.smallpawsrescue.org/pup3/revolution.html

http://www.fda.gov/cvm/Documents/CVMFortDodgeDocument.doc

nbc5i.com - Family - Heartworm Medicine Linked To Sickness, Death
(http://www.nbc5i.com/family/3345322/detail.html)
Scroll down to see chart about Revolution which states:
"Revolution (Selamectin): Total adverse reactions 8695. Total Deaths 181. Year Approved. 1999"

<Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST! 
Date: 6/6/2004 9:18:35 PM Central Daylight Time
From: Londeb29@aol.com
To: Pup3

I can't believe it, it happened to my adopted bichon Shelby AKA Sante Fe Sandi on May 14, 2004. I decided to contact Pfizer after my vet politely told me to try it again the next month and if they same thing happened again then I should change flea medication. Pfizer has refunded my money for the Revolution and I am now trying to get paid for the vet bill. The dosage is too stronge for our delicate bichons.  The drug range is under 10lbs or 10 to 20 lbs and Shelby is only 11 lbs which is what the vet told me I needed due to Shelby's increase in weight. My vet gave Shelby a few injections and it took 3 days for her to begin to move around again. She is doing better but has not been the same since. I should have notified my bichon family as I thought this was an isolated incident. I am so sorry I may have been able to save Bear from this terrible toxic drug.
 
Sincerely Debbie Perryman
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Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST!/ Information about Revolution! 
Date: 6/6/2004 4:33:40 PM Central Daylight Time
From: susankoehrn@insightbb.com
To: pup3@aol.com

Canine Revolution Dangers
(http://www.doglogic.com/revolution.htm)


Dale, I have attached a website that describes 2 experiences with Revolution and at the bottom of the site has additional links to get even more info about side effects, etc. It sounds like some very bad stuff. We should all be looking for natural/organic ways to help our babies. Chemicals kill! I hope this info helps even a little. Our bichons cannot handle drugs of any kind. Take care, Susan 
________________________________________________________________________________________________________________  

Subj: Re: EMERGENCY! STOP, DROP and PRAY REQUEST! 
Date: 6/6/2004 3:48:36 PM Central Daylight Time
From: Nancyhakala@aol.com
To: Pup3

Hi Dale,
 
Thanks so much for the update. There have been many dogs who have become critically ill and have even died from Revolution. :(
 
Praying for this little one's recovery,
 
Nancy>

<I called my vet the other day. He did state that he recommends Revolution for cats, but has discontinued the sale of it for dogs.  He stated that he has witnessed dogs get very sick from Revolution & even die from the product!  In May of 2002, I had a very healthy yellow lab, named Zack,  that all of a sudden died one Sunday afternoon.  He was okay one minute & the next we found him lying in the bushes beside our house.  Zack was dead.  A week earlier he was given Revolution.  Revolution was contacted, but stated they had no complaints or any adverse reactions that had been reported to their company & did absolutely nothing.  Revolution is the most expensive product on the market today.  Consumers need to realize & be made aware that these inexpensive as

well as "top of the line" (expensive) "flea & tick control products" are both dangerous & DEADLY.
Nicole  8/3/05<

<If anyone would like to help me with my crusade to put this company out of business, please contact me. 

animalnutzo@yahoo.com



Laura  8/23/05



PS. We also had a really bad reaction two years ago with one of my dogs to Revolution.  The company never responded.  Our dog was in the ICU for three days and was on massive amounts of medication to counter act the reaction to that product. >

<Last week our blind epileptic 4 year old lab received a flea treatment.  Our Vet checked the product information sheet before applying the widely used treatment of Revolution.  There was nothing to indicate he could not receive a treatment.  We are an Animal Sanctuary and use the product always without so much as a question as we regard it as safe.  Our lab came into contact with some rescued kittens that had fleas which is why we gave him the treatment, more as a preventative measure.   We love our boy very much and spare nothing on his care (he broke his two front legs and spent over $8000.00 on surgery to fix them)



Anyway, three days after applying Revolution our epileptic dog who has seizures like clockwork every three weeks, went into a series of cluster seizures.  We brought him to our regular Vet who had him transferred over to an emergency centre.  We started to rule out what was causing the clustering.  That
is when I remembered the Revolution treatment.

I called the drug company and asked in desperation if possibly this is what could have caused his cluster seizures.   Their response was "Based on your dog's history of epilepsy, he would not be a

good candidate for our product."   When I asked them why they simply could not put that in the product information leaflet, Their response "Not enough research to warrent so."   They also explained the time of 3 days after application as to time of seizing.  It takes that long to be absorbed into the central nervous system.

Our Vet was furious, as she had no idea and she felt horrible as she truly loves our special dog, nearly as much as we do.

Our boy survived the clusters (THANK GOODNESS), and the drug company has agreed to pay for all the bloodwork we did, however we are on our own for the other $1000.00 we spent on the emergency ICU care to pull him through.

We love our boy, and would never do anything to harm him, why can they not just put this stuff on the label?????Kelli  8/30/05

Pfizer will only reimburse my fee's associated with bloodwork...not the 36 hour care in ICU or the IV hookup or medication.  They said that is in accordance with their policy.

They also said they have no information linking dogs with epilepsy going into cluster seizures, so they will not change the general product information sheet due to my one epileptic dog having a (possible) reaction.

His blood was so obscured the day of the cluster seizures the bloodwork was useless, so they had to redraw blood today.  CBC toxology, phenobarb/KBR therapeutic test, thyroid test etc...

I am just worried sick for the next month until this stuff is suppose to be out of his system.

His epilepsy is controlled to like I said earlier..1 seizure every three weeks....seems odd that three days after receiving revolution (the only change) he went into a series of cluster seizures :(



Why do they not want to put the "possible side effect" on their general information sheet?



I now have told three of our Vet's about it, and they said they were NEVER  told about that possible

side effect ever.



Kelli  8/30/05





Pfizer claims they have no information linking Revolution with cluster seizures when it's used on dogs with epilepsy.  However, they DO have information linking Revolution with serious adverse drug experiences (ADEs) when it's used on "sick, debilitated or underweight animals."  That's why the FDA made Pfizer put a warning on their label in 2002, stating, "Do not use in sick, debilitated or underweight animals"  That's also why Pfizer's representative told you, "Based on your dog's history of epilepsy, he would not be a good candidate for our product." 



Here is a document from the FDA's Center for Veterinary Medicine concerning adverse reactions to heartworm drugs for dogs (including Selamectin, which is the generic name for Pfizer's Revolution):



http://www.fda.gov/cvm/Documents/CVMFortDodgeDocument.doc



James TerBush